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OSI-930

CAT: 0804-HY-10204-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10204-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OSI-930 is an orally selective inhibitor of Kit, KDR and CSF-1R (c-Fms) with IC50s of 80 nM, 9 nM and 15 nM, respectively. OSI-930 also moderately inhibits Flt-1, c-Raf, Lck and low activity against PDGFRα/β, Flt-3 and Abl. OSI-930 has antitumor activity[1].
CAS Number
728033-96-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; c-Fms; c-Kit; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/OSI-930.html
Purity
99.01
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NCC2=CC=NC3=CC=CC=C23)C=CS1)NC4=CC=C(OC(F)(F)F)C=C4
Molecular Formula
C22H16F3N3O2S
Molecular Weight
443.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Garton AJ, et al. OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models. Cancer Res. 2006, 66 (2) :1015-1024.|[2]Lin HL, et al. Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug. Drug Metab Dispos. 2011, 39 (2), 345-350.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
VEGFR1/Flt-1; VEGFR2/KDR/Flk-1

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