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Hydroflumethiazide (Standard)

CAT: 0804-HY-W011240RSize: 1 EachDry Ice: NoHazardous: No
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Description
Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3].
CAS Number
135-09-1
Product Name Alternative
Methforylthiazidine (Standard) ; Rontyl (Standard)
UNSPSC
12352005
Hazard Statement
H317-H334
Target
Chloride Channel; Reference Standards; Sodium Channel
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hydroflumethiazide-standard.html
Smiles
O=S(C1=C(C(F)(F)F)C=C(C2=C1)NCNS2(=O)=O)(N)=O
Molecular Formula
C8H8F3N3O4S2
Molecular Weight
331.28
Precautions
P261-P280-P284-P304+P340
References & Citations
[1]Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11 (1) :103-7.|[2]Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14 (1) :29-37.|[3]Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34 (8) :784-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Hydroflumethiazide

Hydroflumethiazide is a benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. It has a role as a diuretic and an antihypertensive agent. It is a thiazide and a benzothiadiazine.

CAS Number135-09-1
PubChem CID3647
IUPAC Name1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Molecular FormulaC8H8F3N3O4S2
Molecular Weight331.3
XLogP0.4
Topological Polar Surface Area135
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity578
SMILES
C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1
InChI
InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
InChIKey
DMDGGSIALPNSEE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hydroflumethiazide
CAS: 135-09-1
CID: 3647
Formula: C8H8F3N3O4S2
MW: 331.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.3
XLogP30.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count1
Exact Mass330.99083258
Monoisotopic Mass330.99083258
Topological Polar Surface Area135 Ų
Heavy Atom Count20
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
TRC-H714630-1GHydroflumethiazide
A17897-100Hydroflumethiazide 100mg
sc-280792Hydroflumethiazide-13CD2
013290Hydroflumethiazide-d2
A17897-500Hydroflumethiazide 500mg
A17897-50Hydroflumethiazide 50mg
A17897-10Hydroflumethiazide 10mg
A17897-5Hydroflumethiazide 5mg
AR-H07721-01N4-Nitroso Hydroflumethiazide
AR-H07719-01Hydroflumethiazide-13C-d2

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