Hydroflumethiazide (Standard)

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Description

Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3].

CAS Number

135-09-1

Product Name Alternative

Methforylthiazidine (Standard) ; Rontyl (Standard)

UNSPSC

12352005

Hazard Statement

H317-H334

Target

Chloride Channel; Reference Standards; Sodium Channel

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hydroflumethiazide-standard.html

Smiles

O=S(C1=C(C(F)(F)F)C=C(C2=C1)NCNS2(=O)=O)(N)=O

Molecular Formula

C8H8F3N3O4S2

Molecular Weight

331.28

Precautions

P261-P280-P284-P304+P340

References & Citations

[1]Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11 (1) :103-7.|[2]Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14 (1) :29-37.|[3]Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34 (8) :784-9.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Chemical Information

Hydroflumethiazide

Hydroflumethiazide is a benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. It has a role as a diuretic and an antihypertensive agent. It is a thiazide and a benzothiadiazine.

CAS Number	135-09-1
PubChem CID	3647
IUPAC Name	1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Molecular Formula	C8H8F3N3O4S2
Molecular Weight	331.3
XLogP	0.4
Topological Polar Surface Area	135
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	1
Heavy Atom Count	20
Formal Charge	0
Complexity	578

SMILES

C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1

InChI

InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

InChIKey

DMDGGSIALPNSEE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 135-09-1

CID: 3647

Formula: C8H8F3N3O4S2

MW: 331.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	331.3
XLogP3	0.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	1
Exact Mass	330.99083258
Monoisotopic Mass	330.99083258
Topological Polar Surface Area	135 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	578
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
TRC-H714630-1G	Hydroflumethiazide
sc-280792	Hydroflumethiazide-13CD2
A17897-100	Hydroflumethiazide 100mg
013290	Hydroflumethiazide-d2
A17897-500	Hydroflumethiazide 500mg
A17897-50	Hydroflumethiazide 50mg
A17897-10	Hydroflumethiazide 10mg
A17897-5	Hydroflumethiazide 5mg
AR-H07721-01	N4-Nitroso Hydroflumethiazide
AR-H07719-01	Hydroflumethiazide-13C-d2

Hydroflumethiazide (Standard)

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