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Hydroflumethiazide

CAT: 0804-HY-W011240-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W011240-01Size:5 mg
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Description
Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3].
CAS Number
[135-09-1]
Product Name Alternative
Methforylthiazidine; Rontyl
UNSPSC
12352005
Hazard Statement
H317, H334
Target
Chloride Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hydroflumethiazide.html
Purity
99.38
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=C(C(F)(F)F)C=C(C2=C1)NCNS2(=O)=O)(N)=O
Molecular Formula
C8H8F3N3O4S2
Molecular Weight
331.30
Precautions
H317, H334
References & Citations
[1]Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11 (1) :103-7.|[2]Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14 (1) :29-37.|[3]Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34 (8) :784-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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