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Hydroflumethiazide

CAT: 0572-TRC-H714630-1GSize: 1 gDry Ice: NoHazardous: No
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CAT#:0572-TRC-H714630-1GSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
135-09-1
Synonyms
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide; 3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiazide-7-sulfonamide 1,1-dioxide; 3,4-Dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine 1,1-dioxide; 3,4-Dihydro-7-sulfamoyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-1,2,4-benzothiadiazine 1,1-dioxide; 3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Trifluoromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; 7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; Bristab; Bristurin; Di-Ademil; Dihydroflumethiazide; Diucardin; Diumide K; Diuredemina; Diurometon; Elodrine; Finuret; Flutizide; Glomerulin; Hidroalogen; Hidroflumetiazid; Hydol; Hydrenox; Hydroflumethiazide; Leodrine; Metflorylthiazidine; Methforylthiazidine; NSC 44627; NaClex; NaClex (Glaxo); Olmagran; Rodiuran; Rontyl; Saluron; Salutensin; Sisuril; Spandiuril; Trifluoromethylhydrothiazide; Vergonil
Hazard Statement
May cause allergy or asthma symptoms or breathing difficulties if inhaled
Purity
>95% (HPLC)
Smiles
NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F
Molecular Formula
C8 H8 F3 N3 O4 S2
Molecular Weight
331.29
InChI
InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
Additionnal Information
IUPAC name: 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ^{6},2,4-benzothiadiazine-7-sulfonamide
Shipping Conditions
Room Temperature
Storage Conditions
+4°C

Chemical Information

Hydroflumethiazide

Hydroflumethiazide is a benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide. It has a role as a diuretic and an antihypertensive agent. It is a thiazide and a benzothiadiazine.

CAS Number135-09-1
PubChem CID3647
IUPAC Name1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Molecular FormulaC8H8F3N3O4S2
Molecular Weight331.3
XLogP0.4
Topological Polar Surface Area135
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity578
SMILES
C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1
InChI
InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
InChIKey
DMDGGSIALPNSEE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hydroflumethiazide
CAS: 135-09-1
CID: 3647
Formula: C8H8F3N3O4S2
MW: 331.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.3
XLogP30.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count1
Exact Mass330.99083258
Monoisotopic Mass330.99083258
Topological Polar Surface Area135 Ų
Heavy Atom Count20
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
AAA13509-01Hydroflumethiazide
sc-280792Hydroflumethiazide-13CD2
A17897-100Hydroflumethiazide 100mg
013290Hydroflumethiazide-d2
A17897-500Hydroflumethiazide 500mg
HY-W011240RHydroflumethiazide (Standard)
A17897-50Hydroflumethiazide 50mg
A17897-10Hydroflumethiazide 10mg
A17897-5Hydroflumethiazide 5mg
AR-H07721-01N4-Nitroso Hydroflumethiazide

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