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Galanthamine-O-methyl-d3

CAT: 0804-HY-76299S1Size: 2.5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-76299S1Size:2.5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Galanthamine-O-methyl-d3 is the deuterium labeled Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
CAS Number
1279031-09-2
UNSPSC
12352005
Target
Apoptosis; Cholinesterase (ChE) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O(C([2H])([2H])[2H])C1=C2C=3[C@]4([C@@](O2)(C[C@@H](O)C=C4)[H])CCN(C)CC3C=C1
Molecular Formula
C17H18D3NO3
Molecular Weight
290.37
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kita Y, et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl) . 2013 Feb;225 (3) :543-51.|[3]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3 (SI 1) :67-86.|[4]Kuryatov A, et al. Roles of accessory subunits in alpha4beta2 (*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74 (1) :132-43.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

(13,13,13-~2~H_3_)Galanthamine
CAS Number1279031-09-2
PubChem CID45039329
IUPAC Name(1S,12S,14R)-4-methyl-9-(trideuteriomethoxy)-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
Molecular FormulaC17H21NO3
Molecular Weight290.37
XLogP1.8
Topological Polar Surface Area41.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity440
SMILES
[2H]C([2H])([2H])OC1=C2C3=C(CN(CC[C@]34C=C[C@@H](C[C@@H]4O2)O)C)C=C1
InChI
InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1/i2D3
InChIKey
ASUTZQLVASHGKV-WGBMMLDESA-N
Chemical Structure
2D Structure
2D structure of (13,13,13-~2~H_3_)Galanthamine
CAS: 1279031-09-2
CID: 45039329
Formula: C17H21NO3
MW: 290.37
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight290.37
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass290.17097377
Monoisotopic Mass290.17097377
Topological Polar Surface Area41.9 Ų
Heavy Atom Count21
Formal Charge0
Complexity440
Isotope Atom Count3
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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EBC03109-01Galanthamine-o-methyl-d3
sc-218557Galanthamine-O- (methyl-d3) -N- (methyl-d3)
TRC-G188503-1MGGalanthamine-O-(methyl-d3)-N-(methyl-d3)
011171Epi-galanthamine-O-methyl-d3
sc-489546Galanthamine-O-methyl-d3 Hydrobromide
008619N-Desmethyl Galanthamine-O-methyl-d3
sc-218559Galanthamine-O-methyl-d3 N-Oxide
CS-B-00240Galanthamine-N-Methyl-d3 HCl
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