MGAT2-IN-2

• Description :

  MGAT2-IN-2 is a potent and selective acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC50 of 3.4 nM.

• CAS Number :

  [1710630-11-7]

• UNSPSC :

  12352005

• Target :

  Acyltransferase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/MGAT2-IN-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1CCC2=C1C(N3C(CCC3)=O)=CC(S(=O)(NC4=CC=C(F)C=C4F)=O)=C2)NC5=CC=C(C(F)(F)F)C=C5

• Molecular Formula :

  C26H21F5N4O4S

• Molecular Weight :

  580.53

• References & Citations :

  [1]Sato K, et al. Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors. J Med Chem. 2015 May 14;58 (9) :3892-909.|[2]Sato K, et al. Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acylCoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities. Bioorg Med Chem. 2015 Aug 1;23 (15) :4544-60.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGAT2