β-Amyloid (1-28)

• Description:

  β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

• Product Name Alternative:

  Amyloid β-Protein (1-28)

• UNSPSC:

  12352209

• Target:

  Amyloid-β

• Type:

  Peptides

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/_beta_-Amyloid_1-28.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

• Molecular Formula:

  C145H209N41O46

• Molecular Weight:

  3262.51

• References & Citations:

  [1]Kowalik-Jankowska T, et al. Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper (II) ions: a combined potentiometric and spectroscopic study. J Inorg Biochem. 2003 Jul 1;95 (4) :270-82.|[2]Syme CD, et al. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta- (1-28) : insights from a range of complementary spectroscopic techniques. J Biol Chem. 2004 Apr 30;279 (18) :18169-77.|[3]Jing-Ming Shi, et al. Dissecting the behaviour of β-amyloid peptide variants during oligomerization and fibrillation. J Pept Sci. 2017 Nov;23 (11) :810-817.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  109770-29-8