Jionoside A1

• Description :

  Jionoside A1 isolated from Radix Rehmanniae Praeparata displays dose dependent immune-enhancement activity and possesses moderate protective activities on H2O2-treated SH-SY5Y cells[1]. Jionoside A1 has neuroprotective effects and can alleviate the symptoms of ischemic stroke.

• UNSPSC :

  12352005

• Target :

  Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/jionoside-a1.html

• Purity :

  98.58

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=C(O)C=CC(/C=C/C(O[C@H]2[C@@H]([C@H]([C@H](OCCC3=CC(O)=C(O)C=C3)O[C@@H]2CO[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)CO)O)O[C@@]5([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O5)O)O)=O)=C1

• Molecular Formula :

  C36H48O20

• Molecular Weight :

  800.75

• References & Citations :

  [1]Shen L, et al. Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC-MS (n) combined with bioassays. J Pharm Biomed Anal. 2016 Jan 5;117:363-71.|[2]Yu X, Liu X, Mi X, et al. Jionoside A1 alleviates ischemic stroke ischemia/reperfusion injury by promoting Nix-mediated mitophagy. Cell Mol Biol (Noisy-le-grand) . 2023;69 (8) :237-245.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [120444-60-2]