Schinifoline

CAT: 0804-HY-N4164-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N4164-02Size:5 mg

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Description

Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection[1][2].

CAS Number

80554-58-1

UNSPSC

12352005

Hazard Statement

H300, H315, H319, H335

Target

Apoptosis; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/schinifoline.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(CCCCCCC)N(C)C2=C1C=CC=C2

Molecular Formula

C17H23NO

Molecular Weight

257.37

Precautions

H300, H315, H319, H335

References & Citations

[1]Wang CF, et al. Radiosensitizing effect of schinifoline from Zanthoxylum schinifolium Sieb et Zucc on human non-small cell lung cancer A549 cells: a preliminary in vitro investigation. Molecules. 2014 Dec 1;19 (12) :20128-38.|[2]Lu L, et al. Whole transcriptome analysis of schinifoline treatment in Caenorhabditis elegans infected with Candida albicans. Mol Immunol. 2021 Jul;135:312-319.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Chemical Information

Schinifoline

Schinifoline is a member of quinolines.

CAS Number	80554-58-1
PubChem CID	133504
IUPAC Name	2-heptyl-1-methylquinolin-4-one
Molecular Formula	C17H23NO
Molecular Weight	257.37
XLogP	5
Topological Polar Surface Area	20.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Heavy Atom Count	19
Formal Charge	0
Complexity	334

SMILES

CCCCCCCC1=CC(=O)C2=CC=CC=C2N1C

InChI

InChI=1S/C17H23NO/c1-3-4-5-6-7-10-14-13-17(19)15-11-8-9-12-16(15)18(14)2/h8-9,11-13H,3-7,10H2,1-2H3

InChIKey

HCUSLQJBGQJQCB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 80554-58-1

CID: 133504

Formula: C17H23NO

MW: 257.37

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	257.37
XLogP3	5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	257.177964357
Monoisotopic Mass	257.177964357
Topological Polar Surface Area	20.3 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	334
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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MBS5759924	Schinifoline

Schinifoline

Chemical Information

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