BGB-8035
CAT:
804-HY-149051-02
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BGB-8035
- CAS Number: 2283349-24-4
- UNSPSC Description: BGB-8035 is an orally active, highly selective bruton's tyrosine kinase (BTK) inhibitor with IC50s of 1.1 nM, 99 nM, 621 nM for BTK, TEC, EGFR, respectively. BGB-8035 has antitumor and anti-arthritis activity. BGB-8035 has the potential for B-cell malignancies and autoimmune diseases research[1].
- Target Antigen: Btk
- Type: Reference compound
- Related Pathways: Protein Tyrosine Kinase/RTK
- Applications: COVID-19-immunoregulation
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/bgb-8035.html
- Solubility: 10 mM in DMSO
- Smiles: C=CC(N1CCC(CC1)[C@@H]2CCNC3=C(C(C4=CC(OC)=C(C(OC)=C4)C)=NN32)C(N)=O)=O
- Molecular Weight: 453.53
- References & Citations: [1]Yunhang Guo, et al. Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem. 2023 Mar 23;66(6):4025-4044.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported