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Hydrocortisone phosphate

CAT: 0804-HY-B1155Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1155Size:1 Each
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Description
Hydrocortisone phosphate (Hydrocortisone 21-phosphate) is a derivative of the glucocorticoid Hydrocortisone hemisuccinate that increases serum luteinizing hormone (LH) levels. Hydrocortisone phosphate increases the activity of magnesium-dependent polymerases in the nucleolus. Hydrocortisone phosphate also serves as a substrate for alkaline phosphatase to localize phosphatases that hydrolyze steroid phosphates, and the role of alkaline phosphatase has been validated in adult mouse tissues[1][2][3].
CAS Number
3863-59-0
Product Name Alternative
Hydrocortisone 21-phosphate; Cortisol 21-phosphate
UNSPSC
12352211
Hazard Statement
H315-H319-H320
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hydrocortisone-phosphate.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](C(COP(O)(O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Molecular Formula
C21H31O8P
Molecular Weight
442.44
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Botte V, et al. "The hydrocortisone 21-phosphate as substrate for alkaline phosphatase: Histochemical remarks." Histochemie 16.2 (1968) : 195-196.|[2]Jacob, et al. Munro. "Regulation of nucleolar RNA metabolism by hydrocortisone." European Journal of Biochemistry 7.4 (1969) : 449-453.|[3]Kowalski, et al. "Effects of subchronic implantation of hydrocortisone phosphate-releasing osmotic pumps on peripheral gonadotropin levels and estradiol feedback to gonadotropin secretion in the cynomolgus monkey." Neuroendocrinology 57.2 (1993) : 330-339.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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