Hydrocortisone phosphate

• Description :

  Hydrocortisone phosphate (Hydrocortisone 21-phosphate) is a derivative of the glucocorticoid Hydrocortisone hemisuccinate (HY-B1402) that increases serum luteinizing hormone (LH) levels. Hydrocortisone phosphate increases the activity of magnesium-dependent polymerases in the nucleolus. Hydrocortisone phosphate also serves as a substrate for alkaline phosphatase to localize phosphatases that hydrolyze steroid phosphates, and the role of alkaline phosphatase has been validated in adult mouse tissues[1][2][3].

• Product Name Alternative :

  Hydrocortisone 21-phosphate; Cortisol 21-phosphate

• UNSPSC :

  12352211

• Hazard Statement :

  H315-H319-H320

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Endocrinology; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/hydrocortisone-phosphate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]12[C@](C(COP(O)(O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

• Molecular Formula :

  C21H31O8P

• Molecular Weight :

  442.44

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Botte V, et al. "The hydrocortisone 21-phosphate as substrate for alkaline phosphatase: Histochemical remarks." Histochemie 16.2 (1968) : 195-196.|[2]Jacob, et al. Munro. "Regulation of nucleolar RNA metabolism by hydrocortisone." European Journal of Biochemistry 7.4 (1969) : 449-453.|[3]Kowalski, et al. "Effects of subchronic implantation of hydrocortisone phosphate-releasing osmotic pumps on peripheral gonadotropin levels and estradiol feedback to gonadotropin secretion in the cynomolgus monkey." Neuroendocrinology 57.2 (1993) : 330-339.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [3863-59-0]