Hydrocortisone-d7

• Description :

  Hydrocortisone-d7 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

• Product Name Alternative :

  Cortisol-d7

• UNSPSC :

  12352211

• Hazard Statement :

  H360, H373

• Target :

  Endogenous Metabolite; Glucocorticoid Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Inflammation/Immunology; Endocrinology; Cancer

• Purity :

  99.91

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]12[C@](CC[C@]2(O)C(C([2H])([2H])O)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)C

• Molecular Formula :

  C21H23D7O5

• Molecular Weight :

  369.50

• Precautions :

  H360, H373

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.|[3]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[4]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported