Hydrocortisone

• Description:

  Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

• Product Name Alternative:

  Cortisol

• UNSPSC:

  12352211

• Hazard Statement:

  H360, H373

• Target:

  Endogenous Metabolite; Glucocorticoid Receptor

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology; Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Hydrocortisone.html

• Purity:

  99.94

• Solubility:

  DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1

• Molecular Formula:

  C21H30O5

• Molecular Weight:

  362.46

• Precautions:

  H360, H373

• References & Citations:

  [1]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.|[2]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[3]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  50-23-7