Hydrocortisone

• Description :

  Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

• Product Name Alternative :

  Cortisol

• UNSPSC :

  12352211

• Hazard Statement :

  H360, H373

• Target :

  Endogenous Metabolite; Glucocorticoid Receptor

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Endocrinology; Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Hydrocortisone.html

• Purity :

  99.94

• Solubility :

  DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1

• Molecular Formula :

  C21H30O5

• Molecular Weight :

  362.46

• Precautions :

  H360, H373

• References & Citations :

  [1]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.|[2]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[3]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [50-23-7]