Quinine (sulfate hydrate) (Standard)
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804-HY-W010668R
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Quinine (sulfate hydrate) (Standard)
- CAS Number: 6119-70-6
- UNSPSC Description: Quinine (sulfate hydrate) (Standard) is the analytical standard of Quinine (sulfate hydrate). This product is intended for research and analytical applications. Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2].
- Target Antigen: Dengue virus; Flavivirus; Parasite; Potassium Channel
- Type: Reference compound
- Related Pathways: Anti-infection;Membrane Transporter/Ion Channel
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/quinine-sulfate-hydrate-standard.html
- Smiles: O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3.O=S(O)(O)=O.O.O.[0.5]
- Molecular Weight: 409.48
- References & Citations: [1]Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.|[2]Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.|[3] Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44
- Shipping Conditions: Room temperature