AZ7550

CAT: 0804-HY-B0794-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0794-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
CAS Number
[1421373-99-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Drug Metabolite; EGFR; IGF-1R
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/AZ7550.html
Purity
97.09
Solubility
DMSO : 83.33 mg/mL (ultrasonic; adjust pH to 5 with 1 M HCL)
Smiles
C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O
Molecular Formula
C27H31N7O2
Molecular Weight
485.58
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Citation 01
Biopharm Drug Dispos. 2023 Apr;44 (2) :165-174.|J Pharm Biomed Anal. 2025 Jan 3:255:116662.|bioRxiv. 2024 Jul 2:2024.06.27.600680.|Patent. US20250275968A1.

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