AZ7550

• Description :

  AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  Drug Metabolite; EGFR; IGF-1R

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/AZ7550.html

• Purity :

  97.09

• Solubility :

  DMSO : 83.33 mg/mL (ultrasonic; adjust pH to 5 with 1 M HCL)

• Smiles :

  C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)=O

• Molecular Formula :

  C27H31N7O2

• Molecular Weight :

  485.58

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations :

  [1]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Citation 01 :

  Biopharm Drug Dispos. 2023 Apr;44 (2) :165-174.|J Pharm Biomed Anal. 2025 Jan 3:255:116662.|bioRxiv. 2024 Jul 2:2024.06.27.600680.|Patent. US20250275968A1.

• CAS Number :

  [1421373-99-0]