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AZ7550

CAT: 0013-GTR19204431-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204431-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ7550, the active metabolite of the third-generation EGFR inhibitor AZD9291 (Osimertinib), also functions as an IGF1R inhibitor with an IC50 of 1.6 μM. This compound is a valuable research tool for studying IGF1R signaling in cancer models, applicable in both in vitro biochemical assays and in vivo research exploring resistance mechanisms.
CAS Number
1421373-99-0
Product Name Alternative
ALK, ACK1, AZ7550, AZ-7550, BLK, BTK, AZ 7550, Drug Metabolite, DrugMetabolite, BRK, HER1, Ins R, INSR, IGF1R, IGF-1R, EGFR, Epidermal growth factor receptor, FAK, ErbB4, ErbB-1, FES, FLT4, FLT3, Inhibitor, IRR, inhibit, MNK2, MLK1, PYK2, Tyrosine Kinases, TyrosineKinases, Txk, TEC
Field of Research
Cardiovascular Research, Metabolism Research, Signal Transduction
Purity
97.07% (May vary between batches)
Solubility
DMSO:2.56 mg/mL (5.27 mM)
Smiles
CN1C=C (C=2C1=CC=CC2) C3=NC (NC4=C (OC) C=C (N (CCNC) C) C (NC (C=C) =O) =C4) =NC=C3
Molecular Formula
C27H31N7O2
Molecular Weight
485.58
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide
CAS Number1421373-99-0
PubChem CID71496459
IUPAC NameN-[4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide
Molecular FormulaC27H31N7O2
Molecular Weight485.6
XLogP3.3
Topological Polar Surface Area96.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count36
Formal Charge0
Complexity724
SMILES
CNCCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C)OC
InChI
InChI=1S/C27H31N7O2/c1-6-26(35)30-21-15-22(25(36-5)16-24(21)33(3)14-13-28-2)32-27-29-12-11-20(31-27)19-17-34(4)23-10-8-7-9-18(19)23/h6-12,15-17,28H,1,13-14H2,2-5H3,(H,30,35)(H,29,31,32)
InChIKey
ZROCWKZRGJYPTG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[4-Methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide
CAS: 1421373-99-0
CID: 71496459
Formula: C27H31N7O2
MW: 485.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight485.6
XLogP33.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass485.25392326
Monoisotopic Mass485.25392326
Topological Polar Surface Area96.3 Ų
Heavy Atom Count36
Formal Charge0
Complexity724
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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