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L-Eflornithine

CAT: 0804-HY-B0744CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0744CSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1[1].
CAS Number
66640-93-5
Product Name Alternative
L-DFMO; L-RMI71782; L-α-difluoromethylornithine
UNSPSC
12352211
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L-Eflornithine.html
Solubility
10 mM in DMSO
Smiles
N[C@](CCCN)(C(F)F)C(O)=O
Molecular Formula
C6H12F2N2O2
Molecular Weight
182.17
References & Citations
[1]Qu N, et al. Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J. 2003 Oct 15;375 (Pt 2) :465-70.|[2]Jansson-Löfmark R, et al. Enantiospecific reassessment of the pharmacokinetics and pharmacodynamics of oral eflornithine against late-stage Trypanosoma brucei gambiense sleeping sickness. Antimicrob Agents Chemother. 2015 Feb;59 (2) :1299-307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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