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Eflornithine (hydrochloride)

CAT: 0804-HY-B0744A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0744A-01Size:100 mg
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Description
Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
CAS Number
68278-23-9
Product Name Alternative
DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/eflornithine-hydrochloride.html
Purity
99.90
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
NC(CCCN)(C(F)F)C(O)=O.[H]Cl
Molecular Formula
C6H13ClF2N2O2
Molecular Weight
218.63
Precautions
H302, H312, H332
References & Citations
[1]Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.|[2]Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2 (3) :197-201; discussion 202.|[3]Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23 (5) :1495-501.|[4]Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19 (3) :297-312.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Trypanosoma

Chemical Information

Eflornithine hydrochloride anhydrous

See also: Eflornithine (annotation moved to) ... View More ...

CAS Number68278-23-9
PubChem CID57004
IUPAC Name2,5-diamino-2-(difluoromethyl)pentanoic acid;hydrochloride
Molecular FormulaC6H13ClF2N2O2
Molecular Weight218.63
Topological Polar Surface Area89.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count13
Formal Charge0
Complexity166
SMILES
C(CC(C(F)F)(C(=O)O)N)CN.Cl
InChI
InChI=1S/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H
InChIKey
VKDGNNYJFSHYKD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Eflornithine hydrochloride anhydrous
CAS: 68278-23-9
CID: 57004
Formula: C6H13ClF2N2O2
MW: 218.63
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight218.63
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass218.0633617
Monoisotopic Mass218.0633617
Topological Polar Surface Area89.3 Ų
Heavy Atom Count13
Formal Charge0
Complexity166
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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