Norfloxacin (hydrochloride)

Norfloxacin (hydrochloride)

• CAS Number: 68077-27-0
• UNSPSC Description: Norfloxacin hydrochloride (MK-0366 hydrochloride) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/norfloxacin-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O.Cl
• Molecular Weight: 355.79
• References & Citations: [1]Nelson JM, et al. Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story. Clin Infect Dis. 2007 Apr 1;44(7):977-80. Epub 2007 Feb 14.|[2]Padeiskaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36.|[3]Rafalsky V, et al. Quinolones for uncomplicated acute cystitis in women. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD003597.Nat Commun. 2022 Mar 2;13(1):1116.|Theranostics. 2022 Jan 1;12(3):1187-1203.|Water Res. 2023 May 21, 120110.
• Shipping Conditions: Room temperature
• Clinical Information: Launched