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Fluconazole (mesylate)

CAT: 0804-HY-B0101BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B0101BSize:1 Each
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Description
Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. Target: Antifungal Fluconazole (mesylate) is the mesylate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/l. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10 (-6) M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this [1]. Oral fluconazole was not associated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth defects of previous concern. Fluconazole exposure may confer an increased risk of tetralogy of Fallot [2]. Fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10 mg/kg p.o. every 12 h [3]. Clinical indications: Balanitis; Candida infection; Cryptococcus infection; Cryptococcus neoformans meningitis; Dermatomycosis; Female genital tract infection; Fungal infection; Fungal respiratory tract infection; Fungal urinary tract infection; Prophylaxis; Tinea capitis; Tinea corporis; Tinea cruris; Tinea pedis . Toxicity: Symptoms of overdose include hallucinations and paranoid behavior.
CAS Number
[159532-41-9]
Product Name Alternative
UK 49858 mesylate
UNSPSC
12352005
Target
Antibiotic; Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/fluconazole-mesylate.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C(O)(CN2C=NC=N2)CN3C=NC=N3)C(F)=C1.CS(=O)(O)=O
Molecular Formula
C14H16F2N6O4S
Molecular Weight
402.38
References & Citations
[1]Odds, F.C., S.L. Cheesman, and A.B. Abbott, Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitro. J Antimicrob Chemother, 1986. 18 (4) : p. 473-8.|[2]Molgaard-Nielsen, D., B. Pasternak, and A. Hviid, Use of oral fluconazole during pregnancy and the risk of birth defects. N Engl J Med, 2013. 369 (9) : p. 830-9.|[3]Black, L.A., et al., Pharmacokinetics of fluconazole following intravenous and oral administration to koalas (Phascolarctos cinereus) . J Vet Pharmacol Ther, 2013.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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