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S-8921

CAT: 0804-HY-19298Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19298Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.
CAS Number
151165-96-7
UNSPSC
12352005
Target
Apical Sodium-Dependent Bile Acid Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/S-8921.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C(CC(CC)CC)=O)C(O)=C2C=C(OC)C(OC)=C(OC)C2=C1C3=CC=C(OC)C(OC)=C3)OC
Molecular Formula
C30H36O9
Molecular Weight
540.60
References & Citations
[1]Hara S, et al. S-8921, an ileal Na+/bile acid cotransporter inhibitor decreases serum cholesterol in hamsters. Life Sci. 1997;60 (24) :PL 365-70.|[2]Higaki J, et al. Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18 (8) :1304-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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