ZD-2767

• Description:

  ZD-2767 is an antibody-directed enzyme prodrug therapy (ADEPT) agent. ZD-2767 is composed of the prodrug ZD2767P, carboxypeptidase G2 (CPG2), and the active drug ZD2767D. ZD-2767 achieves tumor-targeted drug delivery through an innovative ADEPT strategy, triggering apoptosis of cancer cells by causing irreparable DNA damage. ZD-2767 can be used for cancer research[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  O=C(O)CC[C@@H](C(O)=O)NC(OC1=CC=C(N(CCI)CCI)C=C1)=O

• Molecular Formula:

  C16H20I2N2O6

• Molecular Weight:

  590.15

• References & Citations:

  [1]Monks NR, et al. Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue. Br J Cancer. 2001 Sep 1;85 (5) :764-71.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [156079-88-8]