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Napsagatran hydrate

CAT: 0804-HY-15759ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15759ASize:1 Each
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Description
Napsagatran (Ro 46-6240) hydrate is a potent thrombin inhibitor. Napsagatran hydrate exhibits anticoagulant effects in vitro and in vivo. Napsagatran hydrate can be used in antithrombotic research[1][2].
CAS Number
159668-20-9
Product Name Alternative
Ro 46-6240 hydrate; Ro 46-6240/010 hydrate
UNSPSC
12352005
Target
Thrombin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Napsagatran_(hydrate).html
Solubility
10 mM in DMSO
Smiles
O=C(NC[C@H]1CN(C(N)=N)CCC1)C[C@@H](C(N(C2CC2)CC(O)=O)=O)NS(C3=CC4=CC=CC=C4C=C3)(=O)=O.O
Molecular Formula
C26H36N6O7S
Molecular Weight
576.67
References & Citations
[1]Roux S, et al. Effects of napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model. J Pharmacol Exp Ther. 1996 Apr;277 (1) :71-8.|[2]Himber J, et al. Inhibition of tissue factor limits the growth of venous thrombus in the rabbit. J Thromb Haemost. 2003 May;1 (5) :889-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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