Hoechst 34580

• Description :

  Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore, Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].

• Product Name Alternative :

  HOE 34580

• UNSPSC :

  12171500

• Hazard Statement :

  H302

• Target :

  Amyloid-β

• Type :

  Dye Reagents

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Hoechst-34580.html

• Purity :

  99.84

• Solubility :

  DMSO : ≥ 47 mg/mL

• Smiles :

  CN1CCN(C2=CC=C3C(N=C(C4=CC=C5C(N=C(C6=CC=C(N(C)C)C=C6)N5)=C4)N3)=C2)CC1

• Molecular Formula :

  C27H29N7

• Molecular Weight :

  451.57

• Precautions :

  H302

• References & Citations :

  [1]Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30 (8) :639-50.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• Citation 01 :

  Free Radic Biol Med. 2024 Sep 17:S0891-5849 (24) 00666-X.|J Lipid Res. 2023 Mar;64 (3) :100338.|Medical University of Vienna. 2025.|Microbiol Res. 2025 Jun 16:299:128259.|PLoS One. 2019 Mar 18;14 (3) :e0213794.

• CAS Number :

  [23555-00-2]