Hoechst 34580

• UNSPSC Description:

  Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].

• Target Antigen:

  Amyloid-β

• Type:

  Dye Reagents

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Hoechst-34580.html

• Purity:

  99.84

• Solubility:

  DMSO : ≥ 47 mg/mL

• Smiles:

  CN1CCN(C2=CC=C3C(N=C(C4=CC=C5C(N=C(C6=CC=C(N(C)C)C=C6)N5)=C4)N3)=C2)CC1

• Molecular Weight:

  451.57

• References & Citations:

  [1]Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.Free Radic Biol Med. 2024 Sep 17:S0891-5849(24)00666-X.|J Lipid Res. 2023 Jan 31;100338.|PLoS One. 2019 Mar 18;14(3):e0213794.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  23555-00-2