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Hoechst S 769121

CAT: 0804-HY-15619-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15619-01Size:5 mg
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Description
Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore, Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].
CAS Number
74681-68-8
Product Name Alternative
Nuclear yellow
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Nuclear-yellow.html
Purity
95.0
Solubility
H2O : ≥ 6 mg/mL
Smiles
[H]Cl.O=S(C1=CC=C(C2=NC3=CC(C4=NC5=CC(N6CCN(C)CC6)=CC=C5N4)=CC=C3N2)C=C1)(N)=O.[H]Cl.[H]Cl
Molecular Formula
C25H28Cl3N7O2S
Molecular Weight
596.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Latt SA, Stetten G, Juergens LA, Recent developments in the detection of deoxyribonucleic acid synthesis by 33258 Hoechst fluorescence. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 23 (7) : 493-505.|[2]a b c "Hoechst Stains". Invitrogren (Molecular Probes) .|[3]Portugal J, Waring MJ. Assignment of DNA binding sites for 4',6-diamidine-2-phenylindole and bisbenzimide (Hoechst 33258) . A comparative footprinting study. Biochimica et Biophysica Acta 949
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

Nuclear yellow

RN from 10th CI, Chem Subs Index; RN refers to tri-HCl

CAS Number74681-68-8
PubChem CID123837
IUPAC Name4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]benzenesulfonamide;trihydrochloride
Molecular FormulaC25H28Cl3N7O2S
Molecular Weight597.0
Topological Polar Surface Area132
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count38
Formal Charge0
Complexity837
SMILES
CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC=C(C=C6)S(=O)(=O)N.Cl.Cl.Cl
InChI
InChI=1S/C25H25N7O2S.3ClH/c1-31-10-12-32(13-11-31)18-5-9-21-23(15-18)30-25(28-21)17-4-8-20-22(14-17)29-24(27-20)16-2-6-19(7-3-16)35(26,33)34;;;/h2-9,14-15H,10-13H2,1H3,(H,27,29)(H,28,30)(H2,26,33,34);3*1H
InChIKey
NZVGXJAQIQJIOY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nuclear yellow
CAS: 74681-68-8
CID: 123837
Formula: C25H28Cl3N7O2S
MW: 597.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight597.0
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass595.109077
Monoisotopic Mass595.109077
Topological Polar Surface Area132 Ų
Heavy Atom Count38
Formal Charge0
Complexity837
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count4
Compound Is CanonicalizedYes

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T19041-01Hoechst S 769121
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