SiR-Hoechst

• UNSPSC Description:

  SiR-Hoechst is a far-red fluorescent DNA probe being used widely for time-lapse imaging of living cells. SiR-Hoechst is minimally toxic at concentrations as high as 10-25 μM. SiR-Hoechst induces DNA damage responses and G2 arrest at concentrations well below 1 μM[1][2].

• Target Antigen:

  DNA Stain

• Type:

  Dye Reagents

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Others

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(CC1)CCN1C2=CC=C(N3)C(N=C3C4=CC=C(N5)C(N=C5C(C=C6)=CC=C6OCCCCNC(C(C=C7)=CC(C(C8=C([Si]9(C)C)C=C(C=C8)N(C)C)=C(C=C/%10)C9=CC%10=[N+](C)/C)=C7C([O-])=O)=O)=C4)=C2

• Molecular Weight:

  950.21

• References & Citations:

  [1]Sen O, et al. The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression. Sci Rep. 2018 May 21;8(1):7898.|[2]Lukinavičius G, et al. SiR-Hoechst is a far-red DNA stain for live-cell nanoscopy. Nat Commun. 2015 Oct 1;6:8497.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported