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Talnetant (hydrochloride)

CAT: 0804-HY-14552ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14552ASize:1 Each
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Description
Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies[1][2][3].
CAS Number
204519-66-4
Product Name Alternative
SB 223412 hydrochloride; SB 223412-A
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/talnetant-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C(N[C@H](C2=CC=CC=C2)CC)=O)C3=C(N=C1C4=CC=CC=C4)C=CC=C3.[H]Cl
Molecular Formula
C25H23ClN2O2
Molecular Weight
418.92
References & Citations
[1]Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S) -N- (1-phenylpropyl) -3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412) . J Med Chem. 1999 Mar 25;42 (6) :1053-65.|[2]Houghton LA, et al. Effect of the NK (3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007 Sep;19 (9) :732-43.|[3]Dawson LA, et al. In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant) : potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33 (7) :1642-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NK3R

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GTR19186414-01Talnetant hydrochloride
A15255-25Talnetant hydrochloride 25mg
A15255-100Talnetant hydrochloride 100mg
A15255-50Talnetant hydrochloride 50mg
A15255-10Talnetant hydrochloride 10mg
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A15254-5Talnetant 5mg
A15254-2Talnetant 2mg

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