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Ezatiostat (hydrochloride)

CAT: 0804-HY-13634Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13634Size:1 Each
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Description
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment[1][2].
CAS Number
286942-97-0
Product Name Alternative
TER199; TLK199 (hydrochloride)
UNSPSC
12352209
Target
Apoptosis; Glutathione S-transferase
Type
Peptides
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ezatiostat-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC)[C@@H](C1=CC=CC=C1)NC([C@@H](NC(CC[C@H](N)C(OCC)=O)=O)CSCC2=CC=CC=C2)=O.Cl
Molecular Formula
C27H36ClN3O6S
Molecular Weight
566.11
References & Citations
[1]Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20|[2]Ruscoe JE, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul;298 (1) :339-45.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2
Citation 01
Cancer Biomark. 2025 Oct;42 (10) :18758592251390145.|Adv Sci (Weinh) . 2023 Mar;10 (7) :e2205262.|Arch Biochem Biophys. 2024 Jul:757:110043.|Cell Res. 2018 Dec;28 (12) :1171-1185. |Free Radic Biol Med. 2024 Jun 19:S0891-5849 (24) 00531-8.|Phytomedicine. 2024 Aug 31:134:155989.|Redox Biol. 2023 May:61:102635.|Redox Biol. 2024 Aug 20:76:103323.

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Alternative Products

CatalogName
B1250-100Ezatiostat hydrochloride
A21222-500Ezatiostat hydrochloride 500mg
A21222-200Ezatiostat hydrochloride 200mg
A21222-100Ezatiostat hydrochloride 100mg
A21222-50Ezatiostat hydrochloride 50mg
A21222-5Ezatiostat hydrochloride 5mg
A21222-2Ezatiostat hydrochloride 2mg
A21222-25Ezatiostat hydrochloride 25mg
A21222-10Ezatiostat hydrochloride 10mg
A21222-10mM-DEzatiostat hydrochloride 10mM * 1mL in DMSO

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