CM-352

• Description :

  CM-352 (compound 5) is an inhibitor of matrix metalloproteinases (MMPs) (MMP-3: IC50=15 nM; MMP-10: IC50=12 nM) . CM-352 has significant antifibrinolytic activity (EC50=0.7 nM) and can significantly prolong blood coagulation time. CM-352 can be used in anti-bleeding research[1].

• UNSPSC :

  12352005

• Target :

  MMP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/cm-352.html

• Smiles :

  O=S([C@]1(CC2(CCNCC2)CC1)C(NO)=O)(C3=CC=C(C=C3)OC4=CC=C(C=C4)C(NC)=O)=O

• Molecular Formula :

  C24H29N3O6S

• Molecular Weight :

  487.57

• References & Citations :

  [1]Orbe J, et al. Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead[J]. Journal of Medicinal Chemistry, 2015, 58 (5) : 2465-2488.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-10; MMP-3

• CAS Number :

  [1664361-37-8]