TTC-352

CAT: 0804-HY-126932Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-126932Size:1 Each
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Description
TTC-352 is an orally bioavailable selective human estrogen receptor (ER) α partial agonist (ShERPA) . TTC-352 inhibits the growth of three ER+ breast cancer cells. TTC-352 induces tumor regression accompanied by exit of ERα from the nucleus to extranuclear sites[1][2].
CAS Number
[1607819-68-0]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ttc-352.html
Smiles
OC1=CC=C(C(C2=CC=C(F)C=C2)=C(OC3=CC=C(O)C=C3)S4)C4=C1
Molecular Formula
C20H13FO3S
Molecular Weight
352.38
References & Citations
[1]Tonetti D A, et al. Efficacy, maximal tolerated dose, and toxicokinetics of TTC-352 in rats and dogs, a partial ER agonist for metastatic ER+ breast cancer[J]. 2017.|[2]Molloy ME, et al. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol Cancer Ther. 2014 Nov;13 (11) :2515-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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