Thalidomide-O-amido-PEG3-C2-NH2 (TFA)

Thalidomide-O-amido-PEG3-C2-NH2 (TFA)

• CAS Number: 1957236-21-3
• UNSPSC Description: Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_14.html
• Purity: 99.55
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCOCCOCCOCCN)=O.FC(F)(F)C(O)=O
• Molecular Weight: 620.53
• References & Citations: [1]BRADNER, James, et al. METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES. WO2017024317A2.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported