PMX 205

• Description :

  PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.

• UNSPSC :

  12352209

• Hazard Statement :

  H315, H319, H335, H412

• Target :

  Complement System

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/PMX_205.html

• Concentration :

  10mM

• Purity :

  99.78

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@](NC(CCC2=CC=CC=C2)=O)([H])CCCNC([C@H](CCCNC(N)=N)NC3=O)=O)=O)=O)CC4CCCCC4)N[C@@]3([H])CC5=CNC6=CC=CC=C56

• Molecular Formula :

  C45H62N10O6

• Molecular Weight :

  839.04

• Precautions :

  H315, H319, H335, H412

• References & Citations :

  [1]Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12 (2) :590-6.|[2]Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181 (12) :8727-34.|[3]Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183 (2) :1375-83.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  Cell Mol Neurobiol. 2023 Jul;43 (5) :1957-1974.|Cell Rep. 2023 Mar 15;42 (3) :112240.|Mol Neurobiol. 2025 Jul 10.|Theranostics. 2019 Oct 12;9 (25) :7566-7582. |Adv Sci (Weinh) . 2024 Jun 5:e2400819.|bioRxiv. 2025 Aug 28:2025.08.22.671883.|Cell Death Dis. 2024 Oct 5;15 (10) :729.|Clin Immunol. 2025 Apr:273:110459.|Int J Cancer. 2023 Jul 1;153 (1) :224-237.|La Trobe University. 2022 Jan.|Nature. 2025 Sep;645 (8082) :1051-1059.

• CAS Number :

  [514814-49-4]