PMX 205

• Description:

  PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.

• UNSPSC:

  12352209

• Hazard Statement:

  H315, H319, H335, H412

• Target:

  Complement System

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/PMX_205.html

• Concentration:

  10mM

• Purity:

  99.78

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@H] (NC ([C@@]1 ([H]) N (CCC1) C ([C@] (NC (CCC2=CC=CC=C2) =O) ([H]) CCCNC ([C@H] (CCCNC (N) =N) NC3=O) =O) =O) =O) CC4CCCCC4) N[C@@]3 ([H]) CC5=CNC6=CC=CC=C56

• Molecular Formula:

  C45H62N10O6

• Molecular Weight:

  839.04

• Precautions:

  H315, H319, H335, H412

• References & Citations:

  [1]Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12 (2) :590-6.|[2]Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181 (12) :8727-34.|[3]Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183 (2) :1375-83.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Cell Mol Neurobiol. 2023 Jul;43 (5) :1957-1974.|Cell Rep. 2023 Mar 15;42 (3) :112240.|Mol Neurobiol. 2025 Jul 10.|Theranostics. 2019 Oct 12;9 (25) :7566-7582. |Adv Sci (Weinh) . 2024 Jun 5:e2400819.|bioRxiv. 2025 Aug 28:2025.08.22.671883.|Cell Death Dis. 2024 Oct 5;15 (10) :729.|Clin Immunol. 2025 Apr:273:110459.|Int J Cancer. 2023 Jul 1;153 (1) :224-237.|La Trobe University. 2022 Jan.|Nature. 2025 Sep;645 (8082) :1051-1059.

• CAS Number:

  514814-49-4