Thalidomide-O-amido-C8-NH2

Thalidomide-O-amido-C8-NH2

• CAS Number: 1950635-15-0
• UNSPSC Description: Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dBRD9-2.html
• Solubility: 10 mM in DMSO
• Smiles: NCCCCCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O
• Molecular Weight: 458.51
• References & Citations: [1]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported