Thalidomide-NH-amido-C8-NH2 (hydrochloride)

Thalidomide-NH-amido-C8-NH2 (hydrochloride)

• CAS Number: 2983057-94-7
• UNSPSC Description: Thalidomide-NH-amido-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
• Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Apoptosis;Autophagy;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/thalidomide-nh-amido-c8-nh2-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(CC1)N2C(C3=CC=CC(NCC(NCCCCCCCCN)=O)=C3C2=O)=O)NC1=O.[H]Cl
• Molecular Weight: 493.98
• References & Citations: [1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported