LYN-1604

• Description :

  LYN-1604 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Autophagy; ULK

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/LYN-1604.html

• Purity :

  99.47

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  ClC1=CC=C(C(CN2CCN(C(CN(CC(C)C)CC(C)C)=O)CC2)OCC3=CC=C(C=CC=C4)C4=C3)C(Cl)=C1

• Molecular Formula :

  C33H43Cl2N3O2

• Molecular Weight :

  584.62

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhang L, et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8 (4) :2687-2701.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ULK1

• Citation 01 :

  Antioxidants (Basel) . 2025 Nov 19;14 (11) :1381.|Cell Signal. 2024 Jun:118:111136.|J Transl Med. 2025 Oct 21;23 (1) :1144.|Biochem J. 2019 Mar 12;476 (5) :875-887.|Oxid Med Cell Longev. 2021 Nov 15:2021:2896674.

• CAS Number :

  [2088939-99-3]