Lyn peptide inhibitor

Lyn peptide inhibitor

• CAS Number: 222018-18-0
• UNSPSC Description: Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of  asthma, allergic, and other eosinophilic disorders[1].
• Target Antigen: Interleukin Related; Src
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/lyn-peptide-inhibitor.html
• Solubility: 10 mM in DMSO
• Smiles: [Stearoyl-YGYRLRRKWEEKIPNP-NH2]
• Molecular Weight: 2370.88
• References & Citations: [1]T Adachi, et al. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162(3):1496-501.|[2]T Adachi, et al. A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J Immunol. 1999 Jul 15;163(2):939-46.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported