DL-AP4 (Standard)

• Description:

  DL-AP4 (Standard) is the analytical standard of DL-AP4. This product is intended for research and analytical applications. DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3].

• Product Name Alternative:

  2-Amino-4-phosphonobutyric acid (Standard)

• UNSPSC:

  12352211

• Target:

  MGluR; Reference Standards

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research:

  Metabolic Disease; Neurological Disease

• Smiles:

  O=C(O)C(N)CCP(O)(O)=O

• Molecular Formula:

  C4H10NO5P

• Molecular Weight:

  183.10

• References & Citations:

  [1]Cull-Candy SG, et al. 2-Amino-4-phosphonobutyric acid as a glutamate antagonist on locust muscle. Nature. 1976 Jul 29;262 (5567) :408-9.|[2]Crooks SL, et al. Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. J Med Chem. 1986 Oct;29 (10) :1988-95.|[3]Yamashita M, et al. Responses of rod bipolar cells isolated from the rat retina to the glutamate agonist 2-amino-4-phosphonobutyric acid (APB) . J Neurosci. 1991 Aug;11 (8) :2372-82.|[4]Ellis EM, et al. Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian. Curr Biol. 2020 Jun 8;30 (11) :R633-R634.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [6323-99-5]