MK-6913

• Description:

  MK-6913 (Tetrahydrofluoroene 52) is a potent and selective estrogen receptor β agonist.

• Product Name Alternative:

  Tetrahydrofluoroene 52

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Tetrahydrofluoroene_52.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C=C2C3=CC=C(N(C(C)(C)C)N=N4)C4=C3C[C@]2(CCOC5=CC=CC=C5)CC1

• Molecular Formula:

  C25H27N3O2

• Molecular Weight:

  401.50

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Matthew L. Maddess, et al. Enantioselective Synthesis of a Highly Substituted Tetrahydrofluorene Derivative as a Potent and Selective Estrogen Receptor Beta Agonist. Org Process Res Dev. 2014 Mar 3;18 (4) : 528–538.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [1398510-92-3]