Chymase-IN-1

• Description:

  Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

• UNSPSC:

  12352005

• Target:

  Proteasome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Chymase-IN-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C2C=CC=CC2=C1)C(P(O)(O)=O)C3=CSC4=CC=C(Cl)C=C43

• Molecular Formula:

  C20H15ClNO4PS

• Molecular Weight:

  431.83

• References & Citations:

  [1]Greco MN, et al. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50 (8) :1727-30.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  862090-74-2