Hydroxy-PEG3- (CH2) 2-Boc

CAT: 0804-HY-42488-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-42488-01Size:500 mg
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Description
Hydroxy-PEG2- (CH2) 2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Hydroxy-PEG2- (CH2) 2-Boc is extracted from patent WO2004008101A2 (compound 196) [1]. Hydroxy-PEG2- (CH2) 2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
CAS Number
[186020-66-6]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxy-peg3-ch2-2-boc.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)CCOCCOCCOCCO
Molecular Formula
C13H26O6
Molecular Weight
278.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Qingqi Chen, et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Non-cleavable Linker; PEG Linkers

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