Hydroxy-PEG2- (CH2) 2-Boc

CAT: 0804-HY-W067061-01Size: 5 gDry Ice: NoHazardous: No
CAT#:0804-HY-W067061-01Size:5 g
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Description
Hydroxy-PEG2- (CH2) 2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Hydroxy-PEG2- (CH2) 2-Boc is extracted from patent WO2004008101A2 (compound 196) [1]. Hydroxy-PEG2- (CH2) 2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
CAS Number
[133803-81-3]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxy-peg2-ch2-2-boc.html
Purity
98.25
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)CCOCCOCCO
Molecular Formula
C11H22O5
Molecular Weight
234.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Qingqi Chen, et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Non-cleavable Linker; PEG Linkers

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