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HORMAD1 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1865Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1865Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The HORMAD1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor HORMAD1 protein expression profile in cells. The kit can be used for measuring the relative amounts of HORMAD1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on HORMAD1.
Synonyms
HORMA domain-containing protein 1 ; Cancer/testis antigen 46 ; CT46 ; Newborn ovary HORMA protein ; HORMAD1 ; NOHMA
Gene Name
HORMAD1 NOHMA
UniProt
Q86X24
Reactivity
Human
Tissue Specificity
Testis-specific. Over-expressed in carcinomas.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.
Molecular Weight
45200 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
HORMA domain-containing protein 1
Subcellular Location
Nucleus. Chromosome. Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity) .

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