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RhoH Colorimetric Cell-Based ELISA

CAT: 0519-EKC1827Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1827Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The RhoH Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor RhoH protein expression profile in cells. The kit can be used for measuring the relative amounts of RhoH in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on RhoH.
Synonyms
Rho-related GTP-binding protein RhoH; GTP-binding protein TTF; Translocation three four protein; RHOH; ARHH, TTF
Gene Name
RHOH
UniProt
Q15669
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis, ulcerative colitis and appendicitis.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca (2+) mobilization in mast cells (By similarity) . Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.
Molecular Weight
21331 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Rho-related GTP-binding protein RhoH
Subcellular Location
Cytoplasm. Cell membrane; Lipid- anchor; Cytoplasmic side. Colocalizes together with ZAP70 in the immunological synapse.

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