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FOXK1 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1766Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1766Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The FOXK1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXK1 protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXK1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXK1.
Synonyms
Forkhead box protein K1; Myocyte nuclear factor; MNF; FOXK1 ; MNF
Gene Name
FOXK1 MNF
UniProt
P85037
Reactivity
Human, Mouse
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (By similarity) . Important regulatory factor of the myogenic progenitor cell population (By similarity) . Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells (By similarity) . Represses myogenic differentiation by inhibiting MEFC acitivity (By similarity) . Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity) . Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity) . Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136) . Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164) .
Molecular Weight
75457 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Forkhead box protein K1
Subcellular Location
Nucleus. Cytoplasm. (Microbial infection) Accumulates in the nucleus upon viral infection.

UniProtKB · P85037

Forkhead box protein K1

FOXK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P85037
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FOXK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Molecular function

ActivatorDevelopmental proteinDNA-bindingRepressor

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Biological process

DifferentiationHost-virus interactionMyogenesisTranscriptionTranscription regulationUbl conjugation pathway

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