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FRK Colorimetric Cell-Based ELISA

CAT: 0519-EKC1722Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1722Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The FRK Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FRK protein expression profile in cells. The kit can be used for measuring the relative amounts of FRK in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FRK.
Synonyms
Tyrosine-protein kinase FRK;2.7.10.2; FYN-related kinase; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; FRK; PTK5, RAK
Gene Name
FRK
UniProt
P42685
Reactivity
Human, Mouse, Rat
Tissue Specificity
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Molecular Weight
58254 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Tyrosine-protein kinase FRK
Subcellular Location
Cytoplasm. Nucleus. Predominantly found in the nucleus, with a small fraction found in the cell periphery.

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