NR2F6 Colorimetric Cell-Based ELISA

• Description:

  The NR2F6 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor NR2F6 protein expression profile in cells. The kit can be used for measuring the relative amounts of NR2F6 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on NR2F6.

• Synonyms:

  Nuclear receptor subfamily 2 group F member 6; V-erbA-related protein 2; EAR-2; NR2F6; EAR2, ERBAL2

• Gene Name:

  NR2F6

• UniProt:

  P10588

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4 (+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC) .

• Molecular Weight:

  42979 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Nuclear receptor subfamily 2 group F member 6

• Subcellular Location:

  Nucleus.