ADA2L Colorimetric Cell-Based ELISA

• Description:

  The ADA2L Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ADA2L protein expression profile in cells. The kit can be used for measuring the relative amounts of ADA2L in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ADA2L.

• Synonyms:

  Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; ADA2-like protein; TADA2A; TADA2L; KL04P

• Gene Name:

  TADA2A

• UniProt:

  O75478

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity) . Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376) . May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376) .

• Molecular Weight:

  51506 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Transcriptional adapter 2-alpha

• Subcellular Location:

  Nucleus. Chromosome.