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XRCC4 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1605Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1605Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The XRCC4 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor XRCC4 protein expression profile in cells. The kit can be used for measuring the relative amounts of XRCC4 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on XRCC4.
Synonyms
DNA repair protein XRCC4; X-ray repair cross-complementing protein 4; XRCC4
Gene Name
XRCC4
UniProt
Q13426
Reactivity
Human
Tissue Specificity
Widely expressed.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination. Binds to DNA and to DNA ligase IV (LIG4) . The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Molecular Weight
38287 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
DNA repair protein XRCC4
Subcellular Location
Nucleus.

UniProtKB · Q13426

DNA repair protein XRCC4

XRCC4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13426
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
XRCC4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hXRCC4
EC number
—
Processing
—
Secondary accessions
A8K3X4, Q9BS72, Q9UP94
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeCytoplasmNucleus

Domain

Coiled coil

Disease

Disease variantDwarfism

Biological process

DNA damageDNA recombinationDNA repair

Molecular function

DNA-binding

PTM

Isopeptide bondPhosphoproteinUbl conjugation

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