Products for Research Use Only
RegisterLogin

NMDAR2B Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1405Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0519-EKC1405Size:1 Kit, containing one 96 Well Plate and all necessary reagents
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
The NMDAR2B Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor NMDAR2B protein expression profile in cells. The kit can be used for measuring the relative amounts of NMDAR2B in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on NMDAR2B.
Synonyms
Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B ; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3 ; GRIN2B; NMDAR2B
Gene Name
GRIN2B
UniProt
Q13224
Reactivity
Human, Mouse, Rat
Tissue Specificity
Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg (2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851) . Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626) . In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity) .
Molecular Weight
166367 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Glutamate receptor ionotropic, NMDA 2B
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi- pass membrane protein.

Related Products

CatalogName
EKC2637NMDAR2B (Phospho-Ser1303) Colorimetric Cell-Based ELISA Kit
EKC2093NMDAR2B (Phospho-Tyr1474) Colorimetric Cell-Based ELISA Kit
EKC2599NMDAR2B (Phospho-Tyr1336) Colorimetric Cell-Based ELISA Kit
EKC1404NMDAR1 Colorimetric Cell-Based ELISA Kit
EKC1359MEF2A Colorimetric Cell-Based ELISA Kit
EKC1455PHCA Colorimetric Cell-Based ELISA Kit
EKC1415Osteopontin Colorimetric Cell-Based ELISA Kit
EKC1373MKP1 Colorimetric Cell-Based ELISA Kit
EKC1112Chk1 Colorimetric Cell-Based ELISA Kit
EKC1526Smad1 Colorimetric Cell-Based ELISA Kit

Alternative Products

CatalogName
MBS9500426-01NMDAR2B Colorimetric Cell-Based ELISA Kit
OKAG00915NMDAR2B Colorimetric Cell-Based ELISA Kit (OKAG00915)
MBS9501699-01Phospho-NMDAR2B (Ser1303) Colorimetric Cell-Based ELISA Kit
OKAG00915-96WOKAG00915-96W - NMDAR2B Colorimetric Cell-Based ELISA Kit
MBS9501130-01Phospho-NMDAR2B (Tyr1474) Colorimetric Cell-Based ELISA Kit
MBS9501661-01Phospho-NMDAR2B (Tyr1336) Colorimetric Cell-Based ELISA Kit
OKAG02189Phospho-NMDAR2B (Ser1303) Colorimetric Cell-Based ELISA Kit (OKAG02189)
OKAG02151Phospho-NMDAR2B (Tyr1336) Colorimetric Cell-Based ELISA Kit (OKAG02151)
OKAG01620Phospho-NMDAR2B (Tyr1474) Colorimetric Cell-Based ELISA Kit (OKAG01620)
CB5493NMDAR2B Cell-Based ELISA Kit

Popular Products