Kir6.2 Colorimetric Cell-Based ELISA Kit

• Description:

  The Kir6.2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Kir6.2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Kir6.2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Kir6.2.

• Synonyms:

  ATP-sensitive inward rectifier potassium channel 11; IKATP; IRK11; Inward rectifier K channel Kir6.2; KCNJ11; Potassium channel inwardly rectifying subfamily J member 11

• Gene Name:

  KCNJ11

• UniProt:

  Q14654

• Reactivity:

  Human, Mouse

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity) . Subunit of ATP-sensitive potassium channels (KATP) . Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

• Molecular Weight:

  43541 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  ATP-sensitive inward rectifier potassium channel 11

• Subcellular Location:

  Membrane; Multi-pass membrane protein.